Diet Soda, Sweeteners Can Still Cause Diabetes, Study Finds

Study is the largest examination to date that tracks biochemical changes in the body

Gizmodo reports on research presented by Brian Hoffmann and his team, which carried out what a press release says is the largest study yet to follow the body's biochemical changes after consumption of both sugar and artificial sweeteners.

Doctor Hyman says artificial sweeteners may slow metabolism and affect the brain, which may cause feelings of hunger and result in eating more.

The paper is being presented at the Experimental Biology 2018 conference in San Diego, where other experts will convene to discuss the issue.

"Our stem cell-based studies indicate that low-calorie sweeteners promote additional fat accumulation within cells compared with cells not exposed to these substances, in a dose-dependent fashion-meaning that as the dose of sucralose is increased more cells showed increased fat droplet accumulation", Sabyasachi Sen, associate professor of medicine at George Washington University in Washington, D.C., said in a statement.

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Evidence is building that zero-calorie sweeteners are more harmful than helpful when it comes to America's obesity and diabetes epidemic, with new research announced supporting a direct link between the sugar substitute and negative health effects.

Business is booming for companies that make artificial sweeteners.

After three weeks, the detailed proteomics look into the rats' bloodstream showed more than 200 proteins significantly increased by the higher glucose intake.

When Dr. Hoffman, Ronan, and Hapsula investigated the biochemical changes in the body due to artificial sweeteners, the results were contrary to popular belief, detailed Forbes.

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"We observed that, in moderation, your body has the machinery to handle sugar; it is when the system is overloaded over a long period of time that this machinery breaks down", explains Hoffmann.

They wanted to understand how sugar and sweeteners impact the lining of blood vessels - the vascular endothelium - in both cell cultures and rats. Furthermore, they discovered acesulfame potassium appeared to accumulate in the blood, with a higher concentration.

Aisling Pigott, a dietitian and spokesperson for the British Dietetic Association, told Newsweek he would be cautious when considering the new study because a lot of the research suggesting the negative impacts of artificial sweeteners have been conducted with animals - which have different metabolic pathways than humans. It's just another indication to use replacement sweeteners in moderation.

"We do need to be aware that overuse or excessive use of any products-including sugar or sweeteners-is not beneficial to health", Pigott said.

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